Antiviral

Chiropractic Owatonna MN Wellness Care

Zinc is an important component of the immune system1,2,3,4. Intracellular zinc has been demonstrated to be a potential prophylactic (intended to prevent disease) treatment for a variety of viruses including rhinovirus, adenovirus, coronavirus, influenza, poliovirus, coxsackievirus, and mengovirus5,6,7,8,9,10,11. Zinc requires a zinc ionophore to enter cells. It is estimated that 22-24% of the US adult population does not meet adequate daily intake of zinc12. Zinc supplementation combined with zinc ionophore supplementation may help prophylactically reduce the severity of symptoms associated with various viral infections. Vladimir Zelenko MD has developed a prophylactic treatment protocol that can be accessed at the following link: https://vladimirzelenkomd.com/prophylaxis-protocol/

MEDICAL DISCLAIMER: This information does not constitute a medical diagnosis or medical treatment. Precision Chiropractic Services and Joshua Burnham DC are not giving medical advice. This is freely accessible information that is formatted in a convenient way for the reader to consider. Consult with your medical doctor before making decisions about how to treat infectious disease. Consult with your medical doctor regarding any possible drug interactions between your currently prescribed medications and nutritional supplements.

References

1) Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M, Melino G, Raschellà G. Zinc-finger proteins in health and disease. Cell Death Discov. 2017 Nov 13;3:17071. doi: 10.1038/cddiscovery.2017.71. PMID: 29152378; PMCID: PMC5683310.

2) Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The Role of Zinc in Antiviral Immunity. Adv Nutr. 2019 Jul 1;10(4):696-710. doi: 10.1093/advances/nmz013. PMID: 31305906; PMCID: PMC6628855.

3) Wessels I, Maywald M, Rink L. Zinc as a Gatekeeper of Immune Function. Nutrients. 2017 Nov 25;9(12):1286. doi: 10.3390/nu9121286. PMID: 29186856; PMCID: PMC5748737.

4) Gammoh NZ, Rink L. Zinc in Infection and Inflammation. Nutrients. 2017 Jun 17;9(6):624. doi: 10.3390/nu9060624. PMID: 28629136; PMCID: PMC5490603.

5) Krenn BM, Gaudernak E, Holzer B, Lanke K, Van Kuppeveld FJ, Seipelt J. Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. J Virol. 2009 Jan;83(1):58-64. doi: 10.1128/JVI.01543-08. Epub 2008 Oct 15. PMID: 18922875; PMCID: PMC2612303.

6) Mun K, Punga T. Cellular Zinc Finger Protein 622 Hinders Human Adenovirus Lytic Growth and Limits Binding of the Viral pVII Protein to Virus DNA. J Virol. 2019 Jan 17;93(3):e01628-18. doi: 10.1128/JVI.01628-18. PMID: 30429337; PMCID: PMC6340050.

7) Carlucci PM, Ahuja T, Petrilli C, Rajagopalan H, Jones S, Rahimian J. Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients. J Med Microbiol. 2020 Oct;69(10):1228-1234. doi: 10.1099/jmm.0.001250. Epub 2020 Sep 15. PMID: 32930657; PMCID: PMC7660893.

8) Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, Svistunov AA, Petrakis D, Spandidos DA, Aaseth J, Tsatsakis A, Tinkov AA. Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review). Int J Mol Med. 2020 Jul;46(1):17-26. doi: 10.3892/ijmm.2020.4575. Epub 2020 Apr 14. PMID: 32319538; PMCID: PMC7255455.

9) te Velthuis AJ, van den Worm SH, Sims AC, Baric RS, Snijder EJ, van Hemert MJ. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathog. 2010 Nov 4;6(11):e1001176. doi: 10.1371/journal.ppat.1001176. PMID: 21079686; PMCID: PMC2973827.

10) Margolin L, Luchins J, Margolin D, Margolin M, Lefkowitz S. 20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment. J Evid Based Integr Med. 2021 Jan-Dec;26:2515690X211026193. doi: 10.1177/2515690X211026193. PMID: 34225463; PMCID: PMC8264737.

11) Wessels I, Rolles B, Rink L. The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis. Front Immunol. 2020 Jul 10;11:1712. doi: 10.3389/fimmu.2020.01712. PMID: 32754164; PMCID: PMC7365891.

12) Hess JM, Cifelli CJ, Fulgoni Iii VL. Energy and Nutrient Intake of Americans according to Meeting Current Dairy Recommendations. Nutrients. 2020 Sep 30;12(10):3006. doi: 10.3390/nu12103006. PMID: 33007917; PMCID: PMC7599715.

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